Weak/Substantial Metabolizers, CYP2D6 The development on the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to seven% of the populace has reduced activity from the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These men and women are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic
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